Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway

Rab escort protein 1 ( REP 1 ) in intracellular traffic : a functional and pathophysiological overview Markus

requests to: Dr. rer. medic. Markus N. Preising, Dipl.Biol. (PhD) Department of Pediatric Ophthalmology, Strabismology and Ophthalmogenetics Klinikum, University of Regensburg 93042 Regensburg, Germany Tel: +49-941-944-9276 Fax: +49-941-944-9258 E-mail: markus.preising@klinik. uni-regensburg.de Abstract The intracellular distribution of proteins, compartments, substrates, and products is an act...

Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.

PURPOSE To characterize in detail the disease expression in choroideremia (CHM), a blinding X-linked disease of the retina caused by loss-of-function mutations in Rab Escort Protein 1 (REP-1). CHM is readily diagnosed in the clinic and by molecular testing but has lacked an animal model to test hypotheses and therapeutics. The recent report of a mouse model for CHM prompts the need for reassess...

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

Background The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and Src-YES-associated protein 1 (YAP1) signaling are dually activated during EGFR TKI treatment to l...

Identification of an oncogenic RAB protein.

In a short hairpin RNA screen for genes that affect AKT phosphorylation, we identified the RAB35 small guanosine triphosphatase (GTPase)-a protein previously implicated in endomembrane trafficking-as a regulator of the phosphatidylinositol 3'-OH kinase (PI3K) pathway. Depletion of RAB35 suppresses AKT phosphorylation in response to growth factors, whereas expression of a dominant active GTPase-...

EBV Latent Membrane Protein 1 (LMP1) activates EGFR, STAT3 and ERK through effects on PKCδ